The OMAA is the only museum in the state of Maine devoted exclusively to the exhibition and collection of American art.  The permanent collection includes paintings, sculptures, photography, and graphics.  It houses one of the largest collections of ceramic sculpture by Carl Walters; watercolors by Eliot O’Hara; oils by Henry Strater; and drawings and sculpture by Isabella Howland and Bernard Langlais.

The OMAA collection includes a variety of works by artists associated with the famed Ogunquit art colonies, including Edward Betts, Charles Woodbury, Hamilton Easter Field, and Robert Laurent.

While the museum has a superb assortment of works by Maine-related artists, it is also recognized for the diversity of American artists represented in its collection.  Among the artists comprising the permanent collection are: Peggy Bacon, Will Barnet, Charles Burchfield, Marsden Hartley, Walt Kuhn, Gaston Lachaise, Reginald Marsh, Marguerite and William Zorach.